Combination iminium, enamine and copper(I) cascade catalysis: a carboannulation for the synthesis of cyclopentenes.
نویسندگان
چکیده
A one-pot, multistep reaction cascade to cyclopentenes from alpha,beta-unsaturated ketones and propargylated carbon acids through a combination of organocatalysis and transition metal ion catalysis is reported; the reaction cascade is simple to perform, occurs under mild conditions and is broad in scope.
منابع مشابه
Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product SynthesisFinancial support was provided by the NIHGMS (R01 GM078201-01-01), Merck, and Amgen. B.S. is grateful for a Merck predoctoral fellowship
The discovery of new strategies that emulate nature!s capacity to rapidly construct architectural complexity continues to be a central focus for research and development in the chemical sciences. Recently, our laboratory disclosed the concept of organocascade catalysis, a new chemical paradigm that combines two modes of catalyst activation (iminium and enamine catalysis) into one mechanism, the...
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ورودعنوان ژورنال:
- Chemical communications
دوره 25 شماره
صفحات -
تاریخ انتشار 2008